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PtdIns(3,4,5)P₃-dependent Rac Exchanger 1 (PREX1) Rac-Guanine Nucleotide Exchange Factor (GEF) Activity Promotes Breast Cancer Cell Proliferation and Tumor Growth via Activation of Extracellular Signal-regulated Kinase 1/2 (ERK1/2) Signaling

机译：ptdIns（3,4,5）p 3依赖性Rac交换蛋白1（pREX1）Rac-鸟嘌呤核苷酸交换因子（GEF）活性通过激活细胞外信号调节激酶1/2（ERK1 / 2）促进乳腺癌细胞增殖和肿瘤生长信号

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作者
Liu, HJ; Ooms, LM; Srijakotre, N; Man, J; Vieusseux, J; Waters, JAE; Feng, Y; Bailey, CG; Rasko, JEJ; Price, John; Mitchell, CA;
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年度 2016
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1. Phosphatidylinositol 3,4,5-triphosphate-dependent Rac exchanger 1 (P-Rex-1), a guanine nucleotide exchange factor for Rac, mediates angiogenic responses to stromal cell-derived factor-1/chemokine stromal cell derived factor-1 (SDF-1/CXCL-12) linked to Rac activation, endothelial cell migration, and in vitro angiogenesis. [J] . Carretero Ortega J, Walsh CT, Hernandez Garcia Molecular pharmacology. . 2010,第3期

机译：磷脂酰肌醇3,4,5-三磷酸依赖性Rac交换子1（P-Rex-1），Rac的鸟嘌呤核苷酸交换因子，介导对基质细胞衍生因子-1 /趋化因子基质细胞衍生因子1（SDF）的血管生成反应-1 / CXCL-12）与Rac活化，内皮细胞迁移和体外血管生成有关。
2. Expression of Six1 in luminal breast cancers predicts poor prognosis and promotes increases in tumor initiating cells by activation of extracellular signal-regulated kinase and transforming growth factor-beta signaling pathways [J] . Ritsuko Iwanaga, Chu-An Wang, Douglas S Micalizzi, Breast Cancer Research . 2012,第4期

机译：在腔内乳腺癌中Six1的表达预示不良预后并通过激活细胞外信号调节激酶和转化生长因子-β信号通路促进肿瘤起始细胞的增加
3. The Platelet-Activating Factor Receptor Activates the Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase and Induces Proliferation of Epidermal Cells through an Epidermal Growth Factor-Receptor-Dependent Pathway [J] . Silvio A. Marques, Lady C. Dy, Michael D. Southall, The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics . 2002,第3期

机译：血小板活化因子受体激活细胞外信号调节激酶促分裂原活化的蛋白激酶，并通过表皮生长因子受体依赖性途径诱导表皮细胞增殖。
4. Activation of Androgen Receptor in Prostate Cancer: Role of Protein Kinase A and Extracellular Signal-regulated Kinases [C] . Yehia Daaka, Elizabeth Kasbohm, Charles Yowel International Symposium on Hormonal Carcinogenesis . 2005

机译：前列腺癌中雄激素受体的激活 - 蛋白激酶A和细胞外信号调节激酶的作用
5. Signaling pathway from the A(2B) adenosine receptor to extracellular signal-regulated kinases (ERK1/2) in human umbilical vein endothelial cells (HUVEC) and its role in HUVEC proliferation [D] . Fang, Ying 2006

机译：从A（2B）腺苷受体到人脐静脉内皮细胞（HUVEC）中细胞外信号调节激酶（ERK1 / 2）的信号通路及其在HUVEC增殖中的作用
6. PtdIns(345)P3-dependent Rac Exchanger 1 (PREX1) Rac-Guanine Nucleotide Exchange Factor (GEF) Activity Promotes Breast Cancer Cell Proliferation and Tumor Growth via Activation of Extracellular Signal-regulated Kinase 1/2 (ERK1/2) Signaling [O] . Heng-Jia Liu, Lisa M. Ooms, Nuthasuda Srijakotre, 2016

机译：PtdIns（345）P3依赖的Rac交换子1（PREX1）Rac-鸟嘌呤核苷酸交换因子（GEF）活性通过激活细胞外信号调节激酶1/2（ERK1 / 2）促进乳腺癌细胞增殖和肿瘤生长）信令
7. Expression of Six1 in luminal breast cancers predicts poor prognosis and promotes increases in tumor initiating cells by activation of extracellular signal-regulated kinase and transforming growth factor-beta signaling pathways [O] . Ritsuko Iwanaga, Chu-An Wang, Douglas S Micalizzi, 2012

机译：在腔内乳腺癌中Six1的表达预示不良预后并通过激活细胞外信号调节激酶和转化生长因子-β信号通路促进肿瘤起始细胞的增加

PtdIns(3,4,5)P₃-dependent Rac Exchanger 1 (PREX1) Rac-Guanine Nucleotide Exchange Factor (GEF) Activity Promotes Breast Cancer Cell Proliferation and Tumor Growth via Activation of Extracellular Signal-regulated Kinase 1/2 (ERK1/2) Signaling

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